Sustaining Nigeria’s economic growth in the midst of hardship is a collective responsibility which requires collective efforts of entire citizens, irrespective of diversities. This study examined Mathematics instruction as a tool for achieving economic growth, most especially during difficult period. Samples of 150 Science teachers were purposively selected from Oke-Ogun Federal Constituency of Oyo State. A 20-item questionnaire was used to elicit reaction and for data collection. Mean was used to analyze the data collected. The results of the study revealed that Mathematics concepts and strategies used to deliver the subject matter have a lot of role to play in solving societal problems. Based on these results, it was concluded that attention must be given to Mathematics instruction as a mechanism for sustaining strong economy development and growth. And recommended among others, that Mathematics concepts should be selected to reflect the culture, needs, demand, and aspirations of the society based on the criterion of significance.