Human trafficking, especially of the young ones, into exploitative sexual and hard labour has attracted local, national and international attention. Therefore the study investigated human trafficking as consequence of poverty in Afijio Local Government Area of Oyo State. The study adopted descriptive survey research design. The instrument used for this study was questionnaire titled “Human Trafficking as consequence of Poverty and Unemployment (HTACPU)” with a reliability coefficient of 0.81.The data were analyzed using ANCOVA. The results revealed that there is significant influence of trafficking in persons on basis of poverty, and there is no significant influence of trafficking in persons on unemployment rate in Afijio Local Government  Also, the result revealed that there is no significant influence of trafficking in persons on poverty among the youths in Afijio Local Government .The study therefore concludes and recommends that poverty, unemployment and human trafficking have diverse impacts on individuals and the society. Thus, society should be protected by the government from becoming vulnerable to human trafficking through the provisions of jobs, security and qualitative education to prevent people from going out of country to look for greener pasture and quality education in other climes.